Chlorhexidine–alcohol versus iodine–alcohol for surgical site skin preparation in an elective arthroplasty (ACAISA) study: a cluster randomized controlled trial

TN Peel; MM Dowsey; KL Buising; AC Cheng; PFM Choong

Journal article

Chlorhexidine–alcohol versus iodine–alcohol for surgical site skin preparation in an elective arthroplasty (ACAISA) study: a cluster randomized controlled trial

TN Peel, MM Dowsey, KL Buising, AC Cheng, PFM Choong

Clinical Microbiology and Infection | ELSEVIER SCI LTD | Published : 2019

DOI: 10.1016/j.cmi.2019.06.016

Abstract

Objectives: Surgical site skin preparation is an effective method to prevent wound complications. The optimal agent has not been established, and guidelines contain conflicting recommendations. Methods: The aim of alcoholic chlorhexidine or alcoholic iodine skin antisepsis (ACAISA) was to assess the efficacy of surgical site skin preparation with 0.5% chlorhexidine gluconate (w/v) in 70% ethanol (v/v) to 1% iodine (w/v) in 70% ethanol (v/v). This was a cluster randomized, controlled, single-centre, assessor-blinded, superiority trial in patients undergoing elective hip or knee arthroplasty. Each surgeon had a set operating day and the unit of randomization was the day of surgery. The primary..

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University of Melbourne Researchers

Michelle Dowsey Author

Kirsty Buising Author

Peter Choong Author

Related Projects (2)

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors declare that they have no competing interests. This trial was funded by the National Health and Medical Research Council (NHMRC) of Australia, grant number APP1057736. The funder had no role in the design, data analysis or the preparation of the manuscript. Doctor Trisha Peel is supported by an NHMRC Career Development Fellowship (APP1140350). Associate Professor Michelle Dowsey is supported by a NHMRC Career Development Fellowship (APP1122526). Professor Allen Cheng is supported by a NHMRC Career Development Fellowship (APP1068732). Professor Peter Choong is supported by a NHMRC Practitioner Fellowship (APP1154203).